Between 1980 and 1992, 3176 patients with adenocarcinoma of stomach underwent surgical treatment at the department of Surgery. Kosin Medical Collage. The purpose of this study was to evaluate clinical characteristics according to the WHO and
Laurens
classification and the implication of both classifications as a prognostic factor in stage Ⅲgastric cancer. The clinical characteristic according to the histopathologic factor in stage Ⅲgastric cancer. The clinical characteristic according to
the
histopathologic classification were evaluated in 788 patients with stage Ⅲgastric cancer who underwent gastrectomy. The relation of pathologic features according to WHO and Laurens classification and prognoss was studied. The 788 patients were
classified as papillary type(11/788 1.40%), tubular well differenciated(136/788 17.26%), tubular moderate differenciated(202/788 25.6%), poor differenciated(320/788 40.6%) mucinous(62/788 7.8%), signet ring cell(50/788 6.35%). And others(7/788
0.8%)
according to WHO, and as intestinal (399/788 50.6%), diffuse(293/788 37.1%), mixed(96/788 12.8%) according to Lauren. Carcinoma of tubular well differenciated and moderate differenciated were mostly intestinal type and carcinoma of poorly
differenciated
type were mostly diffuse type. The poorly differenciated and diffuse type were distributed considerably young age group and Borrmann type Ⅲand Ⅳwere significantly frequentr in tubular poor and diffuse type. But there no significant differences
were in
tumor locations. The 5-years survival rate of stage Ⅲa patients were 63.3% in tubular well differenciated, 52.2% in tubular moderate differenciated, 39.8% in poorly differenciated, 44.1% in mucinous, 67.6% in signet ring cell, and 56.5% in
intestinal,
40.7% in diffuse, 43.96 % in mixed. The 5-years survival rate of stage Ⅲb patients were 40.7% in tubular well differenciate, 36.5% in tubular moderate differencite, 21.9% in poor differenciate, 34.3% in mixed. The combination of WHO histologic
type and
Lauren classification may provide a good prognostic prediction in stage Ⅲgastric cancer.
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